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mlo family

Donated by

  • Ralph Panstruga Plant Microbe Interactions, Max-Planck-Institute for Plant Breeding Research

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mlo genes

In the fungal phylum Ascomycota, the ability to cause disease in plants and animals has been gained and lost repeatedly during phylogenesis.

In monocotyledonous barley, loss-of-function mlo alleles result in effective immunity against the Ascomycete Blumeria graminis f. sp. hordei, the causal agent of powdery mildew disease. This mlo gene family is from the dicotyledonous plant species Arabidopsis thaliana. All these mlo mutations are recessive and the majority confer broad-spectrum powdery mildew resistance to the plants.


  • Consonni, C. et al. 2006. Conserved requirement for a plant host cell protein in powdery mildew pathogenesis. Nature Genetics 38(6): 716-720. PMID. 16732289.